ADIPOQ
Adiponectin, C1Q and Collagen Domain Containing
Gene Number: 9370
Location: 3q27.3
Key Functions: Glucose regulation, insulin sensitivity, fatty acid oxidation, anti-inflammatory signaling
ADIPOQ encodes adiponectin, a hormone secreted primarily by adipose (fat) tissue.
Adiponectin plays a key role in:
Enhancing insulin sensitivity
Promoting fatty acid breakdown
Exerting both anti-inflammatory and anti-atherogenic effects in the body
Low adiponectin levels are associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs266729 | No matching variant or no valid DNA data | G | No interpretation available |
rs2241766 | No matching variant or no valid DNA data | G | No interpretation available |
rs1501299 | No matching variant or no valid DNA data | T | No interpretation available |
rs266729
GC – Intermediate adiponectin levels; potential mixed effect, or lower cancer and metabolic risk (R, R).
CC – Possibly higher metabolic and cancer risk compared to GG/GC, depending on lifestyle and other genetic factors (R, R).
Functional effect: The G allele has been linked to reduced risk of colorectal cancer and slightly better metabolic outcomes in some studies.
rs2241766
TT – Most common genotype (R).
TG – Slightly lower risk of breast cancer (R).
GG – Rare; slightly lower risk of breast cancer (R).
Functional effect: The G allele is associated with reduced breast cancer risk, particularly when combined with certain genotypes at rs1501299.
rs1501299
GG – Typical breast cancer risk (R).
GT – May increase circulating adiponectin levels and lower metabolic disease risk (R).
TT – Higher adiponectin levels; may protect against type 2 diabetes and cardiovascular disease (R).
Functional effect: The T allele has been associated with higher adiponectin production and improved insulin sensitivity.
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