ADIPOQ
Adiponectin, C1Q and Collagen Domain Containing
Gene Number: 9370
Location: 3q27.3
Key Functions: Glucose regulation, insulin sensitivity, fatty acid oxidation, anti-inflammatory signaling
ADIPOQ produces adiponectin, a hormone released mainly by fat cells. Adiponectin helps the body respond to insulin, use fatty acids for energy and regulate inflammation. It connects the activity of fat tissue with glucose and fat metabolism [R].
This report examines rs266729 and rs1501299, two common ADIPOQ variants studied for their relationship with circulating adiponectin and metabolic health.
Explore your genotypes below, or visit MC4R and appetite regulation and FTO and body-weight regulation to understand other genetic influences on metabolic health.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs266729 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
rs1501299 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs266729 — Adiponectin Regulation
GG – Two G alleles. Lower adiponectin levels have been reported in people with this genotype (R, R).
GC – One G allele. Linked to a tendency toward lower circulating adiponectin in some studied populations (R, R).
CC – Reference genotype. No copies of the G allele linked to lower adiponectin levels. Possibly higher metabolic and cancer risk compared to GG/GC, but it is a normal genotype (R, R).
Functional effect: rs266729 lies in the promoter region of ADIPOQ, which helps regulate gene expression. The G allele has been linked to lower circulating adiponectin levels.
rs1501299 — Circulating Adiponectin
GG – Reference genotype. No copies of the T allele linked to higher adiponectin levels. Most common genotype (R).
GT – One T allele. Linked to higher circulating adiponectin in some studied populations (R).
TT – Two T alleles. Linked to higher circulating adiponectin. An Italian study of 2,008 people also reported approximately 42% lower odds of myocardial infarction compared with G-allele carriers (OR 0.58) (R, R).
Functional effect: rs1501299 lies in an intron, a noncoding part of ADIPOQ. It marks variation related to adiponectin levels without changing the hormone’s protein sequence.
What About Colorectal Cancer?
An early study reported approximately 27% lower colorectal-cancer odds among rs266729 G-allele carriers (R). However, a later consortium analysis involving 7,020 cases and 7,631 controls found no significant relationship for either variant (R).
Your genotype describes a tendency; a blood test measures your actual adiponectin level.
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