ADIPOQ
Adiponectin, C1Q and Collagen Domain Containing
Gene Number: 9370
Location: 3q27.3
Key Functions: Glucose regulation, insulin sensitivity, fatty acid oxidation, anti-inflammatory signaling
The ADIPOQ (adiponectin) gene encodes a secreted protein hormone that is predominantly synthesized by white adipose tissue and circulates abundantly in the bloodstream. Adiponectin acts as a metabolic regulator, bridging the endocrine functions of adipose tissue with systemic energy homeostasis. It plays a central role in glucose metabolism, lipid oxidation, and inflammatory control, thereby linking adipose biology directly to insulin action and cardiovascular health [R].
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs266729 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
rs1501299 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs266729
CC – Possibly higher metabolic and cancer risk compared to GG/GC, but normal genotype to have (R, R).
Functional effect: The G allele has been linked to reduced risk of colorectal cancer and slightly better metabolic outcomes in some studies.
rs1501299
GG – Typical breast cancer risk. Most common genotype (R).
GT – May increase circulating adiponectin levels and lower metabolic disease risk (R).
TT – Higher adiponectin levels; may protect against type 2 diabetes and cardiovascular disease (R).
Functional effect: The T allele has been associated with higher adiponectin production and improved insulin sensitivity.
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