APC
APC (adenomatous polyposis coli)
Gene Number: 324
Location: 5q22.2
Key Functions: Tumor suppression, Wnt signaling regulation, cell growth and division
APC helps control how cells grow and divide, including cells lining the colon. Its protein regulates beta-catenin, a key part of the Wnt signaling pathway that helps coordinate tissue growth and renewal. Certain pathogenic APC variants cause familial adenomatous polyposis (FAP), an inherited condition involving numerous colorectal polyps [R].
This report examines rs459552, commonly called D1822V in research. This common variation has been studied for its relationship with colorectal cancer and dietary factors, including fiber and calcium intake.
Explore your genotype below, or visit our BRCA1 and BRCA2 reports to learn about other genes involved in tumor suppression.
This report examines one selected variant; it does not screen for FAP or other hereditary colorectal cancer conditions.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs459552 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs459552 — D1822V and Colorectal Health
TT – Two Val1822 copies. Included in the same dietary-association group as AT; the study did not establish greater protection from having two copies [R].
AT – One Val1822 copy. Included in the group in which higher fiber and calcium intake were linked to lower colorectal cancer odds [R].
AA – Common Asp/Asp genotype. No copies of the Val1822 form examined in the dietary-interaction research. This does not mean that fiber or calcium offers you less benefit [R].
Functional effect: rs459552 determines whether APC contains aspartic acid (A allele) or valine (T allele) at position 1822. This common variation is not a pathogenic FAP finding [R].
What Did the Dietary Study Find?
A Portuguese study of 196 colorectal cancer cases and 200 controls grouped AT and TT together. Within this group, higher fiber intake was associated with approximately 50% lower colorectal cancer odds (OR 0.50), and higher calcium intake with approximately 49% lower odds (OR 0.51). These were dietary comparisons—not reductions attributed to the genotype alone [R].
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