APC
APC (adenomatous polyposis coli)
Gene Number: 324
Location: 5q22.2
Key Functions: Tumor suppression, Wnt signaling regulation, cell cycle control, genomic stability
APC encodes adenomatous polyposis coli, a tumor suppressor protein that regulates the Wnt signaling pathway and controls cell growth and adhesion. It plays a key role in preventing uncontrolled cell division by promoting the degradation of β-catenin, a protein involved in cell proliferation.
Loss of APC function is a major cause of familial adenomatous polyposis and increases the risk of colorectal cancer. APC is essential for maintaining tissue homeostasis and preventing malignant transformation.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs459552 | No matching variant or no valid DNA data | A | No interpretation available |
rs11571833
TT –Common; typical APC activity; colorectal cancer (CRC) risk largely depends on other factors (R).
AT – Moderate effect—studies suggest a lower CRC risk when combined with high fiber and calcium intake (R).
AA – Variant associated with enhanced CRC protection in contexts of high dietary fiber and calcium (OR ~0.76 for colon cancer; 95% CI: 0.60–0.9) (R).
Functional effect: The A allele (Val1822) may confer mild protection against colorectal cancer—but only under specific dietary conditions like high fiber and calcium intake. Alone, it’s considered of modest impact, and its role is likely gene–environment-dependent (R).
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