APC
APC (adenomatous polyposis coli)
Gene Number: 324
Location: 5q22.2
Key Functions: Tumor suppression, Wnt signaling regulation, cell cycle control, genomic stability
The APC (adenomatous polyposis coli) gene encodes a large tumor suppressor protein that acts as a cornerstone in maintaining epithelial tissue integrity and controlling cellular proliferation. APC is best known for its central role in the Wnt/β-catenin signaling pathway, a system crucial for regulating cell fate, division, and differentiation.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs459552 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs11571833
TT –Common; typical APC activity; colorectal cancer (CRC) risk largely depends on other factors (R).
AT – Moderate effect—studies suggest a lower CRC risk when combined with high fiber and calcium intake (R).
AA – Variant associated with enhanced CRC protection in contexts of high dietary fiber and calcium (OR ~0.76 for colon cancer; 95% CI: 0.60–0.9) (R).
Functional effect: The A allele (Val1822) may confer mild protection against colorectal cancer—but only under specific dietary conditions like high fiber and calcium intake. Alone, it’s considered of modest impact, and its role is likely gene–environment-dependent (R).
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