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BDNF

Brain Derived Neurotrophic Factor

Gene Number: 627

Location: 11p14.1

Key Functions: Neuroplasticity, brain development, memory


BDNF is one of the most important neurotrophins in the brain. It plays a central role in supporting neural growth, development, and resilience under stress.


  • Neuroplasticity: Helps the brain adapt, rewire, and form new synaptic connections.

  • Cognitive function: Supports learning, memory formation, and emotional regulation.

  • Neuronal survival and repair: Promotes brain cell maintenance and recovery after injury or stress.

  • Mood regulation: Modulates serotonin and dopamine systems linked to depression and anxiety.


Higher BDNF levels are generally associated with better brain health, faster cognitive recovery, and emotional resilience.

SNP ID
Your Genotype
Alternative Alleles
Interpretation
rs6265
No matching variant or no valid DNA data
T
No interpretation available
rs6265 (Val66Met)

  • CC (Val/Val) – Normal risk; common baseline genotype (R).

  • CT (Val/Met) – 2.6× increased risk for ADHD or depression; associated with introversion, impaired motor learning, and somewhat quicker cognitive decline in Alzheimer’s patients (R).

  • TT (Met/Met) – 2.6× increased risk similar phenotypic profile as AG—introversion, depression resistance, impaired motor learning, and accelerated Alzheimer’s decline (R).

Functional effect: The Met allele disrupts activity-dependent BDNF secretion by impairing intracellular trafficking and sortilin binding, which can impact memory, emotional regulation, and response to neuropsychiatric stressors.


Learn more about what you can do to mitigate risks, and other factors involved by becoming a member of GenesUnveiled today!

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