BDNF
Brain Derived Neurotrophic Factor
Gene Number: 627
Location: 11p14.1
Key Functions: Neuroplasticity, brain development, memory
BDNF provides instructions for making brain-derived neurotrophic factor, a protein that supports nerve-cell survival and helps connections between neurons adapt to experience. This adaptability, called synaptic plasticity, contributes to learning and memory [R].
This page explores rs6265, commonly called Val66Met. The variant changes an amino acid in the precursor form of BDNF and can affect how the protein is transported and released by nerve cells. Experimental research found that the Met form reduced BDNF release in response to neuronal activity [R].
Why does BDNF release matter?
BDNF helps active nerve cells strengthen and adjust their connections. Differences in its release provide a biological reason to investigate Val66Met in memory and brain-function research. However, this genotype does not directly measure your BDNF levels or determine your learning ability.
The table below explains your rs6265 result when this marker is available in your DNA file. For a related aspect of brain biology, explore COMT and catecholamine metabolism.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs6265 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs6265 (Val66Met)
CC (Val/Val)— Optimal BDNF; common baseline genotype (R).
CT (Val/Met) — One copy of the Met variant, which has been associated with reduced BDNF release in response to neuronal activity (R).
TT (Met/Met)— Two copies of the Met variant, which has been associated with even more reduced BDNF release in response to neuronal activity (R).
Functional effect: The T (Met) allele disrupts activity-dependent BDNF secretion by impairing intracellular trafficking and sortilin binding, which can impact memory, emotional regulation, and response to neuropsychiatric stressors.
For broader context, explore our Brain Chemistry reports overview. To understand how genetic findings become report interpretations, read How We Build DNA Reports.
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