CACNA1C
Alpha 1C Subunit
Gene Number: 775
Location: 12p13.33
Key Functions: Voltage-gated calcium influx, cardiac excitation–contraction coupling, neuronal excitability, intracellular signaling and gene transcription regulation
CACNA1C encodes part of the Cav1.2 calcium channel, which helps control calcium entry into cells. In the brain, these channels support nerve-cell signaling and processes involved in learning and memory. They also have important functions in the heart and other tissues [R]. The common rs1006737 variant has been studied in relation to bipolar disorder, schizophrenia and recurrent major depression [R].
This free report explains your GG, AG or AA genotype, the reported associations and what researchers have learned about calcium-channel activity. For related aspects of brain biology, explore BDNF and neuroplasticity or COMT and catecholamine breakdown.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs1006737 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
Understanding Your CACNA1C rs1006737 Result
GG – Normal; baseline population frequency, not associated with elevated psychiatric risk (R).
AG – Modestly increased risk; modestly increased odds of bipolar disorder (OR ~1.18) and associations with major depressive disorder and schizophrenia (R).
AA – Increased risk; linked to higher risk of bipolar disorder (OR ~1.18–1.2 per A allele), as well as recurrent major depression and schizophrenia (R).
Functional effect: rs1006737 lies in a noncoding region of CACNA1C. In a laboratory study of human-derived neurons, AA cells showed higher CACNA1C expression and greater calcium-channel current than AG or GG cells (R).
Associations Beyond Bipolar Disorder
A UK study also associated the A allele with recurrent major depression and schizophrenia, reporting allelic odds ratios of approximately 1.15 for each condition in its initial comparisons (R).
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