CACNA1C
Alpha 1C subunit
Gene Number: 775
Location: 12p13.33
Key Functions: Voltage-gated calcium influx, cardiac excitation–contraction coupling, neuronal excitability, intracellular signaling and gene transcription regulation
CACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), which plays a central role in the physiology of excitable tissues by mediating the influx of calcium ions into cells upon membrane depolarization. When a cell reaches a threshold potential, Cav1.2 channels open, permitting Ca²⁺ entry that initiates a cascade of intracellular signaling events fundamental to numerous cellular functions [R].
At GenesUnveiled, your CACNA1C variants contribute to health reports related to mood regulation, stress sensitivity and cognitive processing
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs1006737 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs1006737 (CACNA1C, intronic A>G)
GG – Normal risk; baseline population frequency, not associated with elevated psychiatric risk (R).
AG – Intermediate risk; carriers show modestly increased odds of bipolar disorder (OR ~1.18) and associations with major depressive disorder and schizophrenia (R).
AA – Increased risk; linked to higher risk of bipolar disorder (OR ~1.18–1.2 per A allele), as well as recurrent major depression and schizophrenia (R).
Functional effect: The A allele is associated with altered CACNA1C expression, impacting calcium channel signaling. Carriers show measurable changes in brain structure and function, including frontotemporal connectivity and working memory processing, even in healthy individuals.
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