DNMT3A
DNA Methyltransferase 3 Alpha
Gene Number: 1788
Location: 2p23.3
Key Functions: De novo DNA methylation, epigenetic regulation, cellular differentiation, hematopoiesis
DNMT3A encodes DNA methyltransferase 3 alpha, an enzyme involved in de novo DNA methylation — the process of adding new methylation marks during development and cell fate decisions. Unlike DNMT1, which maintains existing patterns, DNMT3A establishes new methylation landscapes, especially during embryogenesis and stem cell differentiation.
Mutations in DNMT3A are frequently found in hematologic malignancies such as acute myeloid leukemia (AML) and have been linked to disrupted epigenetic programming and impaired blood cell development.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs1550117 | No matching variant or no valid DNA data | G | No interpretation available |
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