DRD2
Dopamine receptor D2
Gene Number: 1813
Location: 11q23.2
Key Functions: Dopamine signaling, reward system regulation, motor control, cognitive function
DRD2 encodes dopamine receptor D2, a receptor critical for mediating dopamine neurotransmission in brain regions involved in motivation, reward processing, movement, and executive function. It plays a vital role in regulating emotional responses, decision-making, and motor activity.
Variations in DRD2 are associated with altered dopamine signaling, affecting risk for addiction, schizophrenia, and movement disorders.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs6277 | No matching variant or no valid DNA data | A | No interpretation available |
rs1800497 | No matching variant or no valid DNA data | A | No interpretation available |
rs1801028 | No matching variant or no valid DNA data | C | No interpretation available |
rs1076560 | No matching variant or no valid DNA data | A | No interpretation available |
rs6277 (C957T)
AA – Normal risk of schizophrenia; associated with faster NoGo learning (R).
AG – ~1.4× higher risk of schizophrenia (R).
GG – C~1.6× higher risk of schizophrenia (R).
Functional effect: The G allele increases DRD2 mRNA stability, elevating receptor expression and altering reward/stress responses.
rs1800497 (Taq1A)
GG A2/A2 – Normal baseline, with standard learning and receptor density (R).
AG A1/A2 – Reduced D2 receptor density, impaired error avoidance, ~0.5× lower OCD risk, ~0.87× lower tardive dyskinesia risk, but higher ADHD and alcohol dependence risk, increased obesity risk, poor smoking cessation response to bupropion (R).
AA A1/A1 – Bad at avoidance of errors. 0.25x lower OCD; 0.56x lower Tardive Diskinesia; higher ADHD; 1.4x Alcohol Dependence; lower Postoperative Nausea; Increased obesity; less pleasure response; Bupropion ineffective for smoking cessation.; 2.4x risk for adenoma recurrence. (R).
Functional effect: The A1 (T) allele, located in ANKK1, lowers D2/3 receptor binding in striatum and affects reinforcement learning and addiction vulnerability.
rs1801028 (Cys311Ser)
GG – Normal risk of schizophrenia (R).
CG – ~1.4× higher risk of schizophrenia (R).
CC – Normal risk of schizophrenia (R).
rs1076560 (C/A)
CC – Normal regarding alcoholism risk; baseline working memory (R).
AC – ~1.3× higher risk of alcoholism (R).
AA – Normal in alcoholism risk but influences working memory function (R).
Functional effect: The A allele shifts DRD2 splicing, altering the ratio between presynaptic D2S and postsynaptic D2L isoforms, impacting addiction risk and emotion processing.
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