F2
Coagulation factor II (prothrombin)
Gene Number: 2147
Location: 11p11.2
Key Functions: Blood coagulation, thrombin production, coagulation cascade regulation, hemostasis balance
F2 encodes coagulation factor II (prothrombin), a glycoprotein precursor that plays a central role in the coagulation cascade, the tightly regulated process responsible for preventing blood loss following vascular injury. Synthesized primarily in the liver, prothrombin requires vitamin K–dependent γ-carboxylation for its biological activity—a modification that enables calcium binding and proper interaction with phospholipid membranes during coagulation.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs1799963 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs1799963
GG – Normal prothrombin levels; typical venous thrombosis risk (R).
GA – One copy of the A allele (20210A) raises circulating prothrombin and VTE risk ~2.8× overall, and ~3.2× in individuals under 45 (R).
AA – Homozygous; rare—OR up to 6.74× for VTE in smaller studies (R).
Functional effect: The A allele increases prothrombin (Factor II) levels, promoting hypercoagulability and significantly raising risk for venous thromboembolism. Carriers on combined oral contraceptives or with Factor V Leiden have even higher risk (R).
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