F5
Coagulation factor V
Gene Number: 2153
Location: 1q24.2
Key Functions: Blood clotting, thrombin generation, regulation of clot formation
F5 provides instructions for making factor V, a protein that helps blood clot after an injury. Activated factor V helps convert prothrombin into thrombin, supporting the formation of the fibrin mesh that stops bleeding [R].
This report examines rs6025, the Factor V Leiden variant. The T allele makes activated factor V harder to switch off, increasing the likelihood of blood clots forming in veins, including deep vein thrombosis (DVT) and pulmonary embolism (PE).
Explore your genotype below, or visit our F2 and prothrombin report to learn about another inherited influence on blood clotting.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs6025 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs6025 — Factor V Leiden
CC – No Factor V Leiden variant detected. Other genetic and non-genetic factors can still influence blood-clot risk [R].
CT – One copy of Factor V Leiden increases venous blood-clot risk. A 2024 meta-analysis estimated approximately 3× the odds of venous thromboembolism compared with noncarriers [R].
TT – Two copies of Factor V Leiden are associated with greater venous blood-clot risk. The same meta-analysis estimated approximately 5.6× the odds compared with noncarriers [R].
Functional effect: Factor V Leiden changes one amino acid in factor V, making its activated form resistant to inactivation by activated protein C. This allows clotting activity to persist longer [R].
Discover the science behind your genetics and securely process your raw data for personalized health insights with a GenesUnveiled membership.