F5
Coagulation factor V
Gene Number: 2153
Location: 1q24.2
Key Functions: Blood coagulation, thrombin generation, clot formation, hemostasis regulation, thrombosis susceptibility
F5 encodes coagulation factor V (FV), a large glycoprotein that plays an indispensable role in the coagulation cascade, serving as a critical procoagulant cofactor that amplifies thrombin generation. It functions as a molecular accelerator in the conversion of prothrombin (factor II) to thrombin (factor IIa)—the central enzyme responsible for fibrin formation and stable blood clot development.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs6025 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs6025
CC – Typical clotting risk (R).
CT – Markedly increased risk of venous thromboembolism; classic Factor V Leiden carrier (R).
TT – Very high thrombosis risk ; homozygous Factor V Leiden (11.4x higher risk of thrombosis) (R).
Functional effect: The A allele causes p.Arg506Gln (R506Q) in Factor V, leading to activated protein C (APC) resistance and a pro-thrombotic state (R).
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