FOXO3
Forkhead box O3
Gene Number: 2309
Location: 6q21
Key Functions: Transcription factor activity, regulation of oxidative stress response, modulation of apoptosis, promotion of autophagy, lifespan regulation
FOXO3 encodes the forkhead box O3 transcription factor, a pivotal member of the FOXO subfamily within the forkhead transcription factor family. These proteins are characterized by a conserved DNA-binding domain known as the forkhead box, enabling them to regulate gene expression critical for cellular homeostasis. FOXO3 plays a central role in modulating various cellular processes, including oxidative stress response, apoptosis, autophagy, metabolism, and DNA repair. Its activity is tightly regulated through post-translational modifications such as phosphorylation, acetylation, and ubiquitination, which influence its nuclear localization and transcriptional activity [R].
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs9400239 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs9400239
TT – Longevity-associated genotype; carriers show increased odds of reaching advanced age and healthier stress-response regulation (R).
CT – Heterozygous; partial longevity benefit, moderate protection compared to C/C (R).
CC – Common genotype; not associated with enhanced lifespan in current studies (R).
Functional effect: The T allele has been linked to exceptional longevity in several cohorts, often in strong linkage with other FOXO3 SNPs (rs2802292, rs2764264). It is thought to promote better cellular stress resistance and metabolic regulation.
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