top of page

HTR2A

5-HT2A serotonin receptor

Gene Number: 3356

Location: 13q14.2

Key Functions: Serotonin signaling, mood regulation, cognitive function, sleep regulation


HTR2A encodes 5-hydroxytryptamine receptor 2A, a key serotonin receptor abundantly expressed in the brain. It regulates neurotransmission and plays an important role in emotional balance, perception, sleep architecture, and cognitive performance.


Genetic variants in HTR2A are linked to altered risk for depression, anxiety, and schizophrenia, and may influence individual response to selective serotonin reuptake inhibitors (SSRIs) and other psychiatric medications.

SNP ID
Your Genotype
Alternative Alleles
Interpretation
rs6313
No matching variant or no valid DNA data
A
No interpretation available
rs6311
No matching variant or no valid DNA data
A,T
No interpretation available
rs6313

  • AA – Normal risk for rheumatoid arthritis (R).

  • AG – Higher risk for rheumatoid arthritis based on haplotype data (R).

  • GG – Higher risk for rheumatoid arthritis (R).

Functional effect: The G allele is part of an HTR2A haplotype (rs6311-rs1328674-rs6313-rs6314) associated with approximately 1.68× increased RA risk.


rs6311

  • TT – Normal (lower) risk of sexual dysfunction when treated with SSRI antidepressants (R).

  • CT – Normal risk of SSRI-related sexual dysfunction (R).

  • CC – ~3.6× increased risk of sexual dysfunction under SSRI treatment (R).

Functional effect: The C allele in the promoter region may influence mRNA expression and SSRI side-effect susceptibility, particularly sexual dysfunction.


Learn more about what you can do to mitigate risks, and other factors involved by becoming a member of GenesUnveiled today!

bottom of page