IL10
Interleukin 10
Gene Number: 3586
Location: 1q32.1
Key Functions: Anti-inflammatory cytokine signaling, immune homeostasis, inhibition of pro-inflammatory cytokine production, regulation of immune tolerance, modulation of infection and autoimmune responses
The IL10 gene produces interleukin-10 (IL-10), an immune signaling protein that helps limit inflammatory responses. It acts as one of the immune system’s brakes, helping control the activity of other immune cells [R].
The variant rs1800896, often called IL10 −1082 A/G, lies in a regulatory region involved in controlling gene expression. Researchers have associated this marker with differences in how much IL-10 immune cells produce. On the forward strand used here, T corresponds to the commonly studied lower-production A allele, while C corresponds to G [R, R].
Explore your available genotype below. For another part of inflammatory signaling, visit our IL23R gene guide.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs1800896 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs1800896 — IL-10 production tendency
TT – Associated with lower IL-10 production in some studies.
TC – Often described as an intermediate-production genotype.
CC – Associated with higher IL-10 production in some studies.
These are research-based tendencies rather than fixed production levels. Studies have linked the −1082 marker to IL-10 secretion, but findings are not uniform across experimental settings (R, R).
What this means: IL-10 helps restrain inflammation, but higher production is not automatically better in every situation. Your genotype does not measure your IL-10 level, current inflammation, or overall disease risk.
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