IL10
Interleukin 10
Gene Number: 3586
Location: 1q32.1
Key Functions: Anti-inflammatory cytokine signaling, immune homeostasis, inhibition of pro-inflammatory cytokine production, regulation of immune tolerance, modulation of infection and autoimmune responses
IL10 encodes interleukin-10, a key anti-inflammatory cytokine that plays a central role in limiting immune reactions and preventing excessive tissue damage during inflammation. It is primarily secreted by monocytes, regulatory T cells (Tregs), B cells, and macrophages. IL-10’s immunoregulatory activity is essential for maintaining the balance between effective pathogen defense and immune tolerance [R].
IL-10 acts through the IL-10 receptor complex (IL10R1/IL10R2), activating the JAK1–STAT3 signaling pathway to suppress transcription of pro-inflammatory genes and promote the expression of anti-inflammatory mediators [R].
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs1800896 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs1800896
Functional effect: The T allele of rs1800896 in the IL10 gene is associated with lower IL-10 production, resulting in a stronger pro-inflammatory immune profile.
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