IL1B
Interleukin 1 Beta
Gene Number: 3553
Location: 2q14
Key Functions: Pro-inflammatory signaling, fever induction, immune system activation
IL1B encodes interleukin-1 beta (IL-1β), a potent pro-inflammatory cytokine involved in innate immunity and fever response. It is synthesized as an inactive precursor and activated through caspase-1 cleavage, typically downstream of inflammasome signaling.
Elevated IL-1β activity has been implicated in autoimmune diseases, chronic inflammatory conditions, cardiovascular disease, and cancer-related inflammation.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs16944 | No matching variant or no valid DNA data | G | No interpretation available |
rs1143634 | No matching variant or no valid DNA data | A | No interpretation available |
rs16944
GG –Elevated IL-1β and LPS response; associated with increased cortisol resistance (R).
AG – Intermediate IL-1β activity; moderate inflammation risk (R).
AA –Lower IL-1β activity; associated with reduced inflammatory signaling (R).
Functional effect: The G allele upregulates IL-1β expression in response to immune triggers, enhancing pro-inflammatory signaling and increasing vulnerability to autoimmune and stress-related conditions.
rs1143634
AA – Highest IL-1β expression; increased pro-inflammatory signaling (R).
AG – Moderately increased IL-1β activity; associated with higher autoimmune and metabolic risk (R).
GG – Baseline IL-1β expression; typical inflammation profile (R).
Functional effect: The A allele enhances IL-1β transcription and cytokine release—elevating inflammatory response—but may confer context-dependent protection in certain acute conditions (R).
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