IL23R
Interleukin-23 receptor
Gene Number: 149233
Location: 1p31.3
Key Functions: Inflammatory signaling, T-helper 17 (Th17) cell regulation, immune response modulation, autoimmune disease susceptibility
The IL23R gene helps immune cells respond to interleukin-23, a signaling protein involved in inflammation. This pathway supports immune defense, but it can also contribute to persistent inflammation in immune-mediated diseases [R]. The best-studied variant, rs11209026, is also called Arg381Gln. Its A allele is associated with lower susceptibility to Crohn’s disease, ulcerative colitis, ankylosing spondylitis, and psoriasis. The size of the association differs between conditions and study populations [R, R, R].
This page covers rs11209026 and rs11465804, two markers studied in relation to inflammatory disease susceptibility. Their effects depend on the condition and population studied.
Explore your available results below. For another part of the genetics of intestinal inflammation, visit our NOD2 gene guide.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs11209026 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs11465804 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
rs11209026 — Arg381Gln: a protective IL23R variant
GG – Common reference genotype (R).
AG – You carry one A allele: associated with lower susceptibility to Crohn’s disease, ulcerative colitis, ankylosing spondylitis, and psoriasis (R).
AA – You carry two A alleles: associated with lower susceptibility to Crohn’s disease, ulcerative colitis, ankylosing spondylitis, and psoriasis (R).
Functional effect: The A allele is protective, reducing autoimmune disease risk. Experimental studies show reduced IL-23 signaling, providing a biological explanation for its association with lower inflammatory disease susceptibility (R, R).
rs11465804 — a noncoding IL23R marker
TT – Normal reference; baseline risk (R).
GT – 0.68× lower risk for ankylosing spondylitis (R).
GG – 0.68x lower risk for spondylitis (R).
Functional effect: The G allele reduces susceptibility to inflammatory joint disease, likely through IL-23 receptor pathway modulation.
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