IL23R
Interleukin-23 receptor
Gene Number: 149233
Location: 1p31.3
Key Functions: Inflammatory signaling, T-helper 17 cell regulation, immune response modulation, autoimmune disease susceptibility
IL23R encodes interleukin-23 receptor, a subunit of the receptor complex for interleukin-23, which plays a central role in promoting inflammation through the maintenance and expansion of Th17 cells. It is essential for immune defense at mucosal surfaces and shaping adaptive immunity.
Genetic variants in IL23R influence susceptibility to a range of autoimmune and inflammatory conditions, including Crohn’s disease, psoriasis, and ankylosing spondylitis, by altering inflammatory signaling pathways.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs11209026 | No matching variant or no valid DNA data | A | No interpretation available |
rs11465804 | No matching variant or no valid DNA data | G | No interpretation available |
rs11209026
GG –Normal; associated with higher risk for certain autoimmune diseases (R).
AG – 0.26× lower risk for several autoimmune diseases (R).
AA – 0.26× lower risk for several autoimmune diseases (R).
Functional effect: The A allele is protective, reducing autoimmune disease risk through altered IL-23 receptor signaling.
rs11465804
TT – Normal reference; baseline risk (R).
CT – 0.68× lower risk for ankylosing spondylitis (R).
CC – 0.68x lower risk for spondylitis (R).
Functional effect: The C allele reduces susceptibility to inflammatory joint disease, likely through IL-23 receptor pathway modulation.
Learn more about what you can do to mitigate risks, and other factors involved by becoming a member of GenesUnveiled today!