IL8
Interleukin 8
Gene Number: 3576
Location: 4q13.3
Key Functions: Chemotaxis, inflammation, neutrophil recruitment, immune signaling
IL8 encodes interleukin-8, also known as CXCL8, a chemokine that plays a major role in the recruitment and activation of neutrophils at sites of infection or injury. It is produced by various cell types in response to inflammatory stimuli.
Overexpression of IL8 has been associated with chronic inflammation, cancer progression, and autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs4073 | No matching variant or no valid DNA data | T | No interpretation available |
rs2227306 | No matching variant or no valid DNA data | T | No interpretation available |
rs4073
AA – Lower IL-8 expression; typically associated with reduced inflammation risk and better outcomes in several conditions, including lymphoid cancers and sepsis (R).
AT – Intermediate IL-8 expression; A may confer partial protection (R).
TT – Increases IL-8 expression in response to LPS and is associated with elevated inflammatory responses (R).
Functional effect: The T allele upregulates IL-8 transcription under inflammatory stimuli, increasing inflammatory cytokine levels and auto-immunity.
rs2227306
CC – Associated with increased IL-8 transcription and elevated cytokine release; variant linked to higher risk of graves disease (R, R).
CT – Likely intermediate effect on IL-8 expression and inflammation markers (R).
TT – Associated with normal IL-8 levels; may reduce inflammation risk (R).
Functional effect: The C allele increases IL-8 transcription and is linked to higher inflammation, particularly in asthma and bronchial conditions (R).
Learn more about what you can do to mitigate risks, and other factors involved by becoming a member of GenesUnveiled today!