IL8
Interleukin 8
Gene Number: 3576
Location: 4q13.3
Key Functions: Chemotaxis, inflammation, neutrophil recruitment, immune signaling
The IL8 gene encodes interleukin-8 (CXCL8), a small yet powerful signaling molecule at the crossroads of inflammation and immunity. Functionally, IL-8 belongs to the CXC chemokine family, acting as a messenger that guides neutrophils — the immune system’s rapid-response soldiers — to sites of infection, tissue damage, or stress.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs4073 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs4073
AA – Lower IL-8 expression; typically associated with reduced inflammation risk and better outcomes in several conditions, including lymphoid cancers and sepsis (R).
AT – Intermediate IL-8 expression; A may confer partial protection (R).
TT – Increases IL-8 expression in response to LPS and is associated with elevated inflammatory responses (R).
Functional effect: The T allele upregulates IL-8 transcription under inflammatory stimuli, increasing inflammatory cytokine levels and auto-immunity.
Learn more about what you can do to mitigate risks, and other factors involved by becoming a member of GenesUnveiled today!