MAPT
Microtubule-associated protein tau
Gene Number: 4137
Location: 17q21.31
Key Functions: Microtubule stabilization, neuronal structure maintenance, axonal transport regulation, cytoskeletal organization, and neurodegeneration prevention
MAPT encodes microtubule-associated protein tau, a fundamental structural protein in neurons that binds to and stabilizes microtubules—the intracellular scaffolds responsible for maintaining cell shape, polarity, and the directed transport of organelles and vesicles along axons and dendrites. Tau ensures the integrity of axonal transport, facilitating the movement of mitochondria, synaptic vesicles, and other essential components required for synaptic communication and neuronal survival.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs143624519 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs143624519 (A152T)
GG –Normal risk; common baseline (R).
AG –~2.5× increased risk for neurodegenerative disorders (R).
AA – ~2.5× increased risk for neurodegenerative disorders (R).
Functional effect: The A allele (A152T) acts as a risk modifier—not directly pathogenic—but modestly raises susceptibility to tauopathies like Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies, likely by altering tau solubility and aggregation.
Discover the science behind your genetics and securely process your raw data for personalized health insights with a GenesUnveiled membership.