MC4R
Melanocortin 4 Receptor
Gene Number: 4160
Location: 18q21.32
Key Functions: Appetite regulation, energy balance, body weight control, glucose metabolism
MC4R, or melanocortin 4 receptor, helps the brain regulate hunger, fullness and energy balance. It receives signals involved in reducing food intake and coordinating how the body uses energy [R].
The common rs17782313 variant, located near MC4R, is linked to differences in body mass index (BMI) and obesity risk [R].
This free report explains your genotype and the findings behind it.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs17782313 | Analyze your DNA to see your genotype | C | Analyze your DNA to see a personalized result. |
Understanding Your MC4R rs17782313 Result
TT – Normal BMI; baseline weight regulation (R).
CT — Slightly higher BMI and obesity risk. One C allele corresponds to approximately 0.22 higher BMI units and 1.12× the odds of obesity compared with TT (R).
CC – Higher BMI and obesity risk. Two C alleles correspond to approximately 0.44 higher BMI units and 1.25× the odds of obesity (R).
Functional effect: The C allele near the MC4R gene is a well-replicated obesity risk variant, influencing appetite regulation, snacking behavior, and BMI increase through hypothalamic pathways.
Appetite, Weight Gain and Metabolic Health
In a study of 5,724 women, the C allele was linked to higher calorie and fat intake. C-allele carriers also experienced approximately 0.2 BMI units more weight gain over one 10-year period than TT carriers. Each C allele was linked to approximately 14% higher odds of type 2 diabetes, after adjustment for BMI and other factors (R).
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