NLRP3
NLR Family Pyrin Domain Containing 3
Gene Number: 114548
Location: 1q44
Key Functions: Inflammasome activation, innate immunity, pro-inflammatory cytokine release
NLRP3 encodes a component of the NLRP3 inflammasome, a multiprotein complex involved in detecting cellular stress, pathogens, and damage-associated signals. Once activated, it promotes the maturation and secretion of pro-inflammatory cytokines like IL-1β and IL-18 via caspase-1.
NLRP3 dysregulation has been linked to chronic inflammation, autoimmune diseases, metabolic disorders, and rare autoinflammatory syndromes like CAPS (Cryopyrin-Associated Periodic Syndromes).
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs35829419 | No matching variant or no valid DNA data | A | No interpretation available |
rs10754558 | No matching variant or no valid DNA data | C | No interpretation available |
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