NOD2
NOD2 (nucleotide-binding oligomerization domain containing 2)
Gene Number: 64127
Location: 16q12.1
Key Functions: Bacterial recognition, innate immune signaling, intestinal defense, inflammation regulation
NOD2 helps cells recognize fragments of bacterial cell walls and activate immune defenses. This bacterial-sensing system is particularly important in the intestine, where the body must manage constant contact with gut microbes [R].
This report examines rs2066844, also called R702W or Arg702Trp, a protein-changing NOD2 variant linked to increased susceptibility to Crohn’s disease, an inflammatory bowel disease [R].
Explore your genotype below. For other genetic influences on intestinal inflammation, visit our guides to IL23R and inflammatory signaling and IL10 and inflammation regulation.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs2066844 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs2066844 — Bacterial Sensing and Crohn’s Disease
CC – Reference genotype. No copies of the T allele associated with increased Crohn’s disease susceptibility at this position.
CT – Increased susceptibility. One T allele. A 2021 DiscovEHR study reported approximately 1.3× the odds of Crohn’s disease [R].
TT – Higher susceptibility. Two T alleles. The same study reported approximately 4× the odds of Crohn’s disease [R].
Functional effect: The T allele changes the amino acid arginine to tryptophan at position 702 of the NOD2 protein. Experimental research links Crohn’s-associated NOD2 variants to weaker responses to muramyl dipeptide, a fragment of bacterial cell walls. This helps explain how altered bacterial sensing can contribute to intestinal inflammation [R, R].
One Part of the Genetic Picture
NOD2 contains other Crohn’s-associated variants, so this result covers one position rather than the whole gene. CC does not rule out Crohn’s disease, and carrying T does not mean you will develop it [R].
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