OPRM1
Opioid receptor mu 1
Gene Number: 4988
Location: 6q25.2
Key Functions: Pain perception, opioid response, reward system regulation, addiction susceptibility
OPRM1 encodes opioid receptor mu 1, the main receptor for endogenous opioids and opioid analgesic drugs such as morphine, fentanyl, and endorphins. It regulates pain relief, mood, and reinforcement of rewarding behaviors through the central nervous system.
Genetic variants in OPRM1 influence pain sensitivity, opioid effectiveness, and susceptibility to addiction. One of the most studied variants, A118G (rs1799971), alters receptor binding and downstream signaling, affecting individual differences in opioid response and dependence risk.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs1799971 | No matching variant or no valid DNA data | G | No interpretation available |
rs9479757 | No matching variant or no valid DNA data | A | No interpretation available |
rs1799971 (A118G)
AA – Normal risk; baseline for pain sensitivity and addiction phenotypes (R).
AG – ~2.5× stronger cravings for alcohol; among alcohol-dependent individuals, naltrexone is ~2× more effective (R).
GG – Higher pain sensitivity (e.g., need more morphine post-surgery) and higher social rejection sensitivity (R).
Functional effect: The G allele (Asp40) may reduce MOR-1 expression and glycosylation, alter β-endorphin affinity, and influence opioid response and addiction behaviors.
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