PPARG
Peroxisome Proliferator-Activated Receptor Gamma
Gene Number: 5468
Location: 3p25.2
Key Functions: Fat-cell development, fat storage, glucose metabolism, insulin sensitivity
PPARG produces a receptor that controls the activity of genes involved in fat storage and glucose metabolism. It helps fat cells develop and influences how the body responds to insulin, the hormone that regulates blood glucose [R].
This report examines rs1801282, also called Pro12Ala.
Explore your genotype below, or visit our ADIPOQ and adiponectin and FTO and body-weight regulation reports to understand other genetic influences on metabolic health.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs1801282 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
rs1801282 — Pro12Ala and Type 2 Diabetes
CC – Pro/Pro. The common comparison genotype. No copies of the Ala12 allele associated with lower type 2 diabetes odds [R].
CG – Pro/Ala. One G allele. A 2020 meta-analysis reported approximately 16% lower type 2 diabetes odds compared with CC [R].
GG – Ala/Ala. Two G alleles. The same analysis reported approximately 32% lower type 2 diabetes odds compared with CC [R].
Functional effect: Pro12Ala replaces proline with alanine at position 12 of the PPARγ2 protein. Laboratory experiments found reduced activation of target genes by the Ala12 form, while human research linked it to improved insulin sensitivity. Lower receptor activity therefore does not automatically mean poorer metabolic function [R].
What About Body Weight?
Lower diabetes risk does not necessarily mean a lower body weight. A separate meta-analysis involving 49,092 people found a small average increase in BMI among G-allele carriers. The weight association varied between studies, so this variant should not be described as a weight-loss advantage [R].
Your genotype describes an inherited tendency; blood glucose and HbA1c tests assess your current glucose regulation.
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