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PPARG

Peroxisome proliferator–activated receptor gamma

Gene Number: 5468

Location: 3p25.2

Key Functions: Fat cell differentiation, glucose metabolism, insulin sensitivity, lipid storage


PPARG encodes peroxisome proliferator-activated receptor gamma, a nuclear receptor that regulates genes involved in adipocyte differentiation, lipid uptake, and glucose metabolism. It plays a critical role in promoting insulin sensitivity, maintaining energy balance, and controlling inflammation within adipose tissue.


Alterations in PPARG function are associated with obesity, insulin resistance, type 2 diabetes, and increased cardiovascular disease risk. Proper PPARG activity is essential for healthy fat storage and long-term metabolic health.

SNP ID
Your Genotype
Alternative Alleles
Interpretation
rs1801282
No matching variant or no valid DNA data
G
No interpretation available
rs1801282

  • CC –Pro/Pro; typical receptor function. No notable impact on T2D or obesity risk (R).

  • CG – Pro/Ala; associated with modest increased BMI and waist circumference (~ 0.08 kg/m² and ~ 0.12 cm respectively), and elevated total cholesterol (~ 0.07 mmol/L). Also linked to ≈18% lower T2D risk overall (OR ≈ 0.82, 95% CI: ~0.77–0.88) (R).

  • GG – Ala/Ala; similar mild increases in adiposity and lipids, with similar protective effect on T2D risk (R).

Functional effect: The G (Ala) allele modestly elevates fatness and cholesterol but improves insulin sensitivity, lowering type 2 diabetes risk. Effects vary by population and environmental context (R).


Learn more about what you can do to mitigate risks, and other factors involved by becoming a member of GenesUnveiled today!

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