RGS2
Regulator of G-protein signaling 2
Gene Number: 5997
Location: 1q31.2
Key Functions: GTPase-activating protein activity for Gα subunits, negative regulation of GPCR signaling, vascular smooth muscle tone, neuronal signaling modulation, stress and anxiety response
RGS2 helps regulate how cells respond to signals, including those from hormones and neurotransmitters. Its protein helps switch off G-protein signaling, influencing how long these messages remain active [R].
The rs4606 variant has been studied in relation to childhood behavioral inhibition, introversion, anxiety disorders and responses to stressful experiences. However, the findings are complex: some studies associate the G allele with anxiety-related traits, while others associate the C allele with generalized anxiety [R].
This free report explains your CC, CG or GG genotype and what the research suggests. For another aspect of neurotransmitter biology, explore COMT and catecholamine breakdown.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs4606 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
Understanding Your RGS2 rs4606 Result
CC — Two C alleles. The C allele was associated with generalized anxiety disorder in one hurricane-exposed population (R).
CG — One C and one G allele. Studies have linked different alleles to different anxiety-related outcomes (R).
GG – Two G alleles. The G allele was associated with childhood behavioral inhibition and adult introversion in one study (R).
What Have Studies Found?
Generalized anxiety disorder: Among 607 hurricane-exposed adults, each C allele was associated with approximately 2× the odds of generalized anxiety disorder (95% confidence interval: 1.1–3.8). This was a study-specific association, not an estimate of your personal likelihood of developing anxiety (R).
Temperament and introversion: Research involving 119 families and 744 adults associated the G allele with childhood behavioral inhibition and adult introversion. A smaller brain-imaging sample also found differences in responses to emotional faces (R).
Post-traumatic stress symptoms: Research in the same hurricane-exposed cohort reported associations involving rs4606, trauma exposure and low social support. The findings suggest that context matters, rather than establishing one universally unfavorable allele (R).
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