RGS2
Regulator of G-protein signaling 2
Gene Number: 5997
Location: 1q31.2
Key Functions: GTPase-activating protein activity for Gα subunits, negative regulation of GPCR signaling, vascular smooth muscle tone, neuronal signaling modulation, stress and anxiety response
RGS2 encodes the Regulator of G-protein Signaling 2, which is an essential member of the RGS protein family. This family of proteins plays a crucial role in the regulation of G-protein-coupled receptor (GPCR) signaling pathways by accelerating the hydrolysis of GTP (guanosine triphosphate) on activated [R].
RGS2 is highly expressed in [R]:
Vascular smooth muscle cells
The heart
Several brain regions, where it modulates vasoconstriction, cardiac function, and neuronal excitability. RGS2 is involved in modulating neuronal excitability and synaptic transmission, which are critical for normal cognitive functions and emotional responses.
At GenesUnveiled, your RGS2 variants contribute to health reports related to stress reactivity, anxiety-related traits and blood pressure regulation.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs4606 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
rs4606
CC – Common genotype; typical anxiety/stress response in most contexts (R).
GC – Intermediate profile; associated with higher trait anxiety and stronger stress-reactive phenotypes in several cohorts (R).
GG – Minor-allele homozygote; linked to social-anxiety traits/introversion and altered limbic activation in some studies (R).
Functional effect: The C allele has the strongest evidence for increased generalized anxiety disorder (≈2× odds per C) and greater PTSD symptom severity under stress.
The G allele has been associated with social-anxiety/introversion in other cohorts. Effects are context-dependent (gene × environment) (R).
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