SLCO1B1
Solute carrier organic anion transporter 1B1
Gene Number: 10599
Location: 12p12.1
Key Functions: Hepatic drug transport, statin metabolism, bilirubin clearance
The SLCO1B1 gene, located on chromosome 12p12.1, encodes the organic anion transporting polypeptide 1B1 (OATP1B1), a key hepatic membrane transporter responsible for shuttling diverse endogenous molecules and xenobiotics from the bloodstream into hepatocytes. Functionally, OATP1B1 acts as a gatekeeper for hepatic drug clearance, mediating the uptake of statins, bilirubin, bile acids, hormones, and therapeutic agents such as methotrexate and repaglinide.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs4149056 | Analyze your DNA to see your genotype | C | Analyze your DNA to see a personalized result. |
rs4149056
TT – Normal SLCO1B1 function; standard statin transport (R).
TC – Reduced SLCO1B1 activity; higher statin exposure; increased myopathy risk (R).
CC – Greatly reduced SLCO1B1 activity; high risk of statin-induced myopathy (R).
Functional effect: The C allele impairs hepatic uptake of statins. For simvastatin 80 mg, the risk of myopathy is ~4.5× per C allele and ~16.9× for CC vs TT (R).
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