SNCA
Synuclein alpha
Gene Number: 6622
Location: 4q22.1
Key Functions: Synaptic function regulation, neurotransmitter release, neuronal plasticity, neurodegeneration prevention
SNCA encodes alpha-synuclein, a presynaptic protein involved in regulating synaptic vesicle trafficking and neurotransmitter release. It plays a vital role in maintaining efficient communication between neurons and supporting brain plasticity under normal conditions.
Abnormal accumulation of alpha-synuclein is a defining feature of Parkinson’s disease and related neurodegenerative disorders known as synucleinopathies, where it forms toxic aggregates that disrupt neuronal integrity.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs356219 | No matching variant or no valid DNA data | A | No interpretation available |
rs11931074 | No matching variant or no valid DNA data | T | No interpretation available |
rs356219
AA – Normal risk for Parkinson’s disease (PD) (R).
AG – ~1.3× increased risk of PD (R).
GG – ~1.6× increased risk of PD (R).
Functional effect: The G allele is linked to higher SNCA (α-synuclein) expression in the substantia nigra and cerebrocerebellar regions and raises PD risk, marking a key tagging SNP for a PD-associated haplotype.
rs11931074
GG – Normal risk for Parkinson’s disease (R).
GT – ~1.3–1.5× increased risk of PD (ethnicity-dependent) (R).
TT – ~1.3–1.4× increased risk of PD, particularly under a recessive model (R).
Functional effect: The T allele in the 3′ region of SNCA is associated with elevated PD susceptibility across multiple populations, likely through effects on α-synuclein expression. The risk magnitude varies by ethnicity and depends on genetic model.
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