SNCA
Synuclein alpha
Gene Number: 6622
Location: 4q22.1
Key Functions: Synaptic function regulation, neurotransmitter release, neuronal plasticity, protein homeostasis, and neurodegeneration prevention
SNCA encodes alpha-synuclein, a small presynaptic neuronal protein that plays a central role in the regulation of synaptic vesicle trafficking, neurotransmitter release, and synaptic plasticity [R, R].
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs356219 | Analyze your DNA to see your genotype | A | Analyze your DNA to see a personalized result. |
rs11931074 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs356219
AA – Normal risk for Parkinson’s disease (PD) (R).
AG – ~1.3× increased risk of PD (R).
GG – ~1.6× increased risk of PD (R).
Functional effect: The G allele is linked to higher SNCA (α-synuclein) expression in the substantia nigra and cerebrocerebellar regions and raises PD risk, marking a key tagging SNP for a PD-associated haplotype.
rs11931074
GG – Normal risk for Parkinson’s disease (R).
GT – ~1.3–1.5× increased risk of PD (ethnicity-dependent) (R).
TT – ~1.3–1.4× increased risk of PD, particularly under a recessive model (R).
Functional effect: The T allele in the 3′ region of SNCA is associated with elevated PD susceptibility across multiple populations, likely through effects on α-synuclein expression. The risk magnitude varies by ethnicity and depends on genetic model.
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