STAT4
Signal Transducer and Activator of Transcription 4
Gene Number: 6775
Location: 2q32.2–q32.3
Key Functions: JAK–STAT signaling, Th1/Th17 differentiation, interferon signaling, cytokine-driven immune activation, autoimmune disease susceptibility
The STAT4 gene helps immune cells respond to chemical signals called cytokines. It produces a protein that switches on genes involved in immune defense and inflammation [R].
Explore your available genotype below. For another gene involved in inflammatory immune responses, visit our IL23R gene guide.
SNP ID | Your Genotype | Alt Allele | Interpretation |
|---|---|---|---|
rs7574865 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs7574865
GG – Baseline risk association with rheumatoid arthritis, SLE, Sjögren’s syndrome, type-1 diabetes, and primary biliary cirrhosis/cholangitis (R).
GT – Increased risk: ~1.3× rheumatoid arthritis; ~1.55× SLE; ~1.42× Sjögren’s syndrome; increased risk of type-1 diabetes; increased risk of primary biliary cirrhosis/cholangitis (R).
TT – Higher risk: ~1.69× rheumatoid arthritis; ~2.4× SLE; ~2.28× Sjögren’s syndrome; increased risk of type-1 diabetes; increased risk of primary biliary cirrhosis/cholangitis (R).
Functional effect: rs7574865 is in a noncoding region of STAT4. In an early-arthritis study, T-allele carriers had higher STAT4 messenger RNA levels, and TT carriers had higher protein levels than GG carriers. This suggests an influence on immune signaling (R).
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