TCF7L2
Transcription factor 7-like 2
Gene Number: 6934
Location: 10q25.2–q25.3
Key Functions: Blood glucose regulation, insulin secretion, Wnt signaling, type 2 diabetes risk
TCF7L2 encodes transcription factor 7 like 2, a key regulator in the Wnt signaling pathway that influences the expression of genes involved in glucose metabolism and insulin secretion. It is essential for maintaining normal blood sugar levels and proper function of pancreatic beta cells.
Genetic variants in TCF7L2 are among the most strongly associated with type 2 diabetes risk. Certain variants impair insulin production, increasing susceptibility to impaired glucose tolerance and diabetes development.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs7903146 | No matching variant or no valid DNA data | T | No interpretation available |
rs4506565 | No matching variant or no valid DNA data | T | No interpretation available |
rs12255372 | No matching variant or no valid DNA data | T | No interpretation available |
rs7903146
CC – Typical risk level for type 2 diabetes (R).
CT – Elevated risk of T2D (OR ≈ 1.41) (R).
TT – High risk of T2D (OR ≈ 1.97) (R).
Functional effect: The T allele reduces insulin secretion and impairs incretin (e.g., GLP-1) action by increasing TCF7L2 expression in pancreatic islets—conferring the strongest inherited T2D risk observed genome-wide (R).
rs4506565
AA – Normal; associated with typical T2D risk (R).
AT – Increased T2D risk (OR ≈ 1.4) (R).
TT – Higher T2D risk (OR ≈ 1.9) (R).
Functional effect: The T allele tags the same disease-associated haplotype as rs7903146 and predicts similar risk and pathophysiological features—making it nearly interchangeable for T2D susceptibility assessments (R).
rs12255372
GG – Baseline diabetes risk (R).
GT – Elevated T2D risk (R).
TT – Elevated T2D risk (stronger than GT) (R).
Functional effect: The T allele disrupts TCF7L2 regulation — potentially by altering enhancer activity — and is strongly linked by GWAS to increased risk of T2D across multiple populations (R).
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