TCF7L2
Transcription factor 7-like 2
Gene Number: 6934
Location: 10q25.2–q25.3
Key Functions: Glucose metabolism regulation, insulin secretion control, Wnt/β-catenin signaling modulation, type 2 diabetes susceptibility
TCF7L2 (transcription factor 7-like 2) encodes a transcription factor that plays a central role in the Wnt signaling pathway, a fundamental molecular cascade involved in cell growth, differentiation, and metabolic regulation. Within the context of metabolism, TCF7L2 acts as a key regulator of genes controlling glucose homeostasis, insulin biosynthesis, and secretion in pancreatic β-cells. It also influences hepatic glucose output and the insulin sensitivity of peripheral tissues.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs7903146 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs4506565 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs12255372 | Analyze your DNA to see your genotype | T | Analyze your DNA to see a personalized result. |
rs7903146
CC – Typical risk level for type 2 diabetes (R).
CT – Elevated risk of T2D (OR ≈ 1.41) (R).
TT – High risk of T2D (OR ≈ 1.97) (R).
Functional effect: The T allele reduces insulin secretion and impairs incretin (e.g., GLP-1) action by increasing TCF7L2 expression in pancreatic islets—conferring the strongest inherited T2D risk observed genome-wide (R).
rs4506565
AA – Normal; associated with typical T2D risk (R).
AT – Increased T2D risk (OR ≈ 1.4) (R).
TT – Higher T2D risk (OR ≈ 1.9) (R).
Functional effect: The T allele tags the same disease-associated haplotype as rs7903146 and predicts similar risk and pathophysiological features—making it nearly interchangeable for T2D susceptibility assessments (R).
rs12255372
GG – Baseline diabetes risk (R).
GT – Elevated T2D risk (R).
TT – Elevated T2D risk (stronger than GT) (R).
Functional effect: The T allele disrupts TCF7L2 regulation — potentially by altering enhancer activity — and is strongly linked by GWAS to increased risk of T2D across multiple populations (R).
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