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TLR4
Toll-Like Receptor 4
Gene Number: 7099
Location: 9q33.1
Key Functions: Innate immune response, pathogen recognition, inflammation signaling
TLR4 encodes Toll-like receptor 4, a membrane-spanning pattern recognition receptor that serves as one of the immune system’s primary sentinels against microbial invasion. Highly expressed on macrophages, dendritic cells, and epithelial cells, TLR4 specializes in detecting lipopolysaccharides (LPS) — major components of the outer membrane of Gram-negative bacteria. Through this recognition, TLR4 acts as an early warning system, translating microbial presence into rapid immune activation.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs4986790 | Analyze your DNA to see your genotype | G | Analyze your DNA to see a personalized result. |
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