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TLR4

Toll-Like Receptor 4

Gene Number: 7099

Location: 9q33.1

Key Functions: Innate immune response, pathogen recognition, inflammation signaling


TLR4 encodes Toll-like receptor 4, a membrane-bound receptor that plays a central role in the innate immune system. It detects bacterial lipopolysaccharides (LPS) and triggers pro-inflammatory signaling cascades to combat infection.


TLR4 activity is essential for pathogen defense but must be tightly regulated. Overactivation or polymorphisms in TLR4 have been associated with autoimmune diseases, chronic inflammation, sepsis, and metabolic disorders.

SNP ID
Your Genotype
Alternative Alleles
Interpretation
rs4986790
No matching variant or no valid DNA data
G
No interpretation available
rs4986791
No matching variant or no valid DNA data
T
No interpretation available

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