TNF
Tumor Necrosis Factor
Gene Number: 7124
Location: 6p21.33
Key Functions: Inflammatory response mediation, immune system activation, apoptosis induction, infection defense
TNF encodes tumor necrosis factor, a pro-inflammatory cytokine involved in regulating immune responses to infection, injury, and cellular stress. It activates immune cells, promotes fever, and facilitates apoptosis in damaged or infected cells.
Overproduction of TNF is a hallmark of several chronic inflammatory and autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis. TNF is also a therapeutic target for biologic drugs aimed at reducing excessive inflammation.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs1800629 | No matching variant or no valid DNA data | A | No interpretation available |
rs361525 | No matching variant or no valid DNA data | A | No interpretation available |
rs1800629 (–308 G>A)
GG – Normal risk; typical baseline TNF-α levels (R).
AG – Higher risk across multiple inflammatory/autoimmune conditions; linked to increased TNF-α expression (R).
AA – Higher risk; often the strongest association with elevated TNF-α and inflammatory phenotypes (R).
Functional effect: The A allele (“TNF2”) upregulates TNF-α transcription from the promoter, raising pro-inflammatory signaling and disease susceptibility in context-dependent ways.
rs361525 (–238 G>A)
GG – Normal risk; common baseline (R).
AG – Higher risk reported for several conditions; may alter TNF-α production (R).
AA – Higher risk (rarer); associations seen in inflammatory and liver-related disorders (R).
Functional effect: The A allele in the TNF-α promoter can modulate expression and downstream inflammation; effect sizes vary by ancestry and disease context.
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