TP53
Tumor Protein P53
Gene Number: 7157
Location: 17p13.1
Key Functions: Tumor suppression, DNA damage response, cell cycle regulation, apoptosis induction
TP53 encodes tumor protein p53, a master regulator of the cellular stress response. It functions as a transcription factor that activates genes involved in DNA repair, cell cycle arrest, and apoptosis to preserve genomic stability and prevent the accumulation of mutations.
Known as the “guardian of the genome,” TP53 plays a pivotal role in protecting against cancer development. Loss or mutation of TP53 is one of the most common events in human cancers and is often associated with poor clinical outcomes.
SNP ID | Your Genotype | Alternative Alleles | Interpretation |
|---|---|---|---|
rs1042522 | No matching variant or no valid DNA data | G | No interpretation available |
rs1042522 (Pro72Arg)
CC (Pro/Pro) – Common variant; associated with slightly shorter lifespan and less effective chemotherapy (R).
CG (Pro/Arg) – Intermediate; possibly slightly improved lifespan compared to CC (R).
GG (Arg/Arg) – 3 years longer lifespan on average; chemotherapy tends to be more effective (R).
Functional effect: The G allele (Arg72 variant) increases apoptotic activity, improves cancer treatment response, and is associated with modest longevity benefits, while the C allele (Pro72) is more common but linked to shorter lifespan and poorer therapy response.
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