SLCO1B1 rs4149056 and Statin Sensitivity Risk

SLCO1B1 rs4149056 affects how your body transports statins and can increase the risk of muscle side effects. Learn what this variant means for statin sensitivity [R].

SLCO1B1 rs4149056: A Key Variant for Statin Sensitivity

The SLCO1B1 rs4149056 variant is a major genetic factor influencing how your body transports statins, especially simvastatin. This SNP can reduce OATP1B1 transporter activity, affecting drug levels and the likelihood of muscle-related side effects [R].

You can analyze your SLCO1B1 rs4149056 result instantly at GenesUnveiled.

How SLCO1B1 rs4149056 Impacts Statin Response

Research shows that the C allele of SLCO1B1 rs4149056 is associated with  [R]:

• Reduced OATP1B1 transporter function

• Higher circulating statin concentrations, especially simvastatin

• Increased risk of statin-induced myopathy

• Lower drug clearance, leading to stronger effects at standard doses

Individuals with CT or CC genotypes typically have reduced transporter efficiency compared to TT carriers.

What This Means for You

If you carry the C allele, studies suggest:

• Higher likelihood of muscle pain or weakness when taking certain statins

• Increased sensitivity to standard dosages

• Doctors may prefer alternative statins or lower doses

If you do not carry the C allele, your statin response is more likely to follow population-average patterns.

Genetics is only one factor—age, medication interactions, exercise, and overall health also influence statin tolerance.

Explore Your Full Mutations Profile

The SLCO1B1 rs4149056 variant is part of the GenesUnveiledmutation analysis reports, alongside many others.

Analyze your complete drug-response profile at GenesUnveiled.