FOXO3 rs9400239 and Longevity Explained

FOXO3 rs9400239 is a longevity-linked genetic variant associated with improved cellular stress response and increased odds of exceptional lifespan in several populations.

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FOXO3 rs9400239: A Longevity-Linked Genetic Variant

The FOXO3 rs9400239 variant has been repeatedly linked to extreme human longevity, especially in individuals who reach age 100 or beyond. This SNP influences FOXO3 activity, a key regulator of stress resistance, metabolic balance, and cellular repair [R, R].

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How FOXO3 rs9400239 Impacts Longevity

Research shows that the T allele of FOXO3 rs9400239 is associated with increased odds of exceptional lifespan. Mechanistically, FOXO3 is central to  [R, R]:

• Oxidative stress defense

• Cellular repair and autophagy

• Insulin/IGF-1 signaling balance

• Inflammatory pathway regulation

These biological functions collectively support healthier aging trajectories.

What This Means for You

If you carry the T allele of FOXO3 rs9400239, studies suggest:

• Higher likelihood of maintaining functional health into old age

• Better cellular resilience to environmental stressors

• More favorable aging-related metabolic patterns

If you do not carry the T allele, your longevity potential still depends heavily on lifestyle, environment, and the rest of your genetic profile.

Explore Your Full Longevity Genetics

The FOXO3 rs9400239 variant is one piece of a broader longevity network involving genes such as APOE, SIRT1, IGF1R, and MTOR.

See your complete profile by uploading your DNA to GenesUnveiled.