IL10 rs1800896 and Inflammation Risk

IL10 rs1800896 influences how your immune system regulates inflammation. Learn how the T risk allele affects IL-10 production and your inflammatory response [R].

IL10 rs1800896: A Key Variant for Inflammation Control

The IL10 rs1800896 variant affects how much IL-10 your immune system produces—a crucial anti-inflammatory cytokine. The T allele (forward strand) is linked to lower IL-10 expression, increasing susceptibility to stronger or prolonged inflammatory responses [R].

You can analyze your IL10 rs1800896 result instantly at GenesUnveiled.

How IL10 rs1800896 Shapes Your Immune Response

Research shows that the T allele of IL10 rs1800896 is associated with [R]:

• Reduced IL-10 production, lowering anti-inflammatory signaling

• Higher inflammatory reactivity when exposed to immune triggers

• Increased susceptibility to autoimmune conditions, depending on other genetic and environmental factors

• Altered balance between pro-inflammatory and anti-inflammatory pathways

In contrast, carriers of the C allele (G in SNPedia notation) tend to have higher IL-10 expression and milder inflammatory activation.

What This Means for You

If you carry the T risk allele of IL10 rs1800896, research suggests:

• You may experience stronger inflammatory responses

• Your baseline immune activation may be slightly elevated

• You may be more reactive to infections, stress, and environmental triggers

Lifestyle factors—sleep, diet, micronutrients, gut health, and chronic stress—significantly influence how this variant expresses itself.

Explore Your Full Immune Health Genetics

The IL10 rs1800896 variant is part of our broader immune-health and inflammation insights, which also include TNF, IL6, IL1B, and CRP-related pathways.

Analyze your full immune profile at GenesUnveiled.