Pharmacogenetics DNA Markers: Quick Overview

Pharmacogenetics DNA markers explore selected genetic variants associated with how people may process or respond to certain medications. Depending on the medication, a marker may examine genetic tendencies related to metabolism, transport, treatment response, dose requirements, or susceptibility to adverse effects.

Already have an active DNA file?

View your Pharmacogenetics markers.

Explore Your Pharmacogenetics Markers

What Our Pharmacogenetics DNA Markers Show

Pharmacogenetics examines how inherited genetic differences may contribute to variation in medication response. Genes can influence several parts of this process, including [R]:

• how quickly a medication is activated or broken down;

• how a medication enters or leaves cells;

• how strongly it interacts with its biological target;

• the concentration of a medication in the body;

• the likelihood of a particular response or adverse effect.

Medication response is never determined by genetics alone. Age, health conditions, organ function, other medications, dose, lifestyle, and treatment adherence can all matter [R].

Examples of Available Markers

The GenesUnveiled collection includes markers related to medications such as:

Example	What the marker explores
Codeine and Tramadol	Selected variants associated with opioid metabolism or response.
Diazepam	Genetic differences studied in relation to diazepam metabolism, including selected variation involving CYP2C19.
Simvastatin	Variants associated with statin transport and susceptibility to muscle-related adverse effects, particularly involving SLCO1B1.

Do Not Change Medication Based on a Marker

Never start, stop, replace, or change the dose of a medication based only on a GenesUnveiled result. If a marker concerns a medication you currently use or may soon receive, discuss it with a doctor or pharmacist. Appropriate clinical pharmacogenetic testing may provide more complete and medically suitable information.

Explore Your Pharmacogenetics Markers

Pharmacogenetics DNA markers can help you explore research connecting selected inherited variants with medication metabolism, transport, response, and adverse effects. They are best used to identify gene–medication relationships worth discussing or investigating further—not as prescribing instructions or substitutes for clinical testing. View all our raw DNA reports & markers.