The FOX (Forkhead Box)  gene family is a critical group of genes that influence diverse biological processes, including cellular development, metabolism, stress resistance, and longevity. With over 40 FOX genes identified in humans, each plays unique roles in maintaining health and preventing disease [ R ]. Among these, FOXO genes  (FOXO1, FOXO3, FOXO4, and FOXO6) have garnered significant attention due to their association with aging, cancer resistance, and metabolic health.