Immune Health

Vitamin D isn't just a vitamin — it's a hormone-like signal that activates over 2,000 genes. And your genetic variants may decide how much you need. Highlights Function Impact on You Key Insight Hormonal signaling Binds to receptors that activate hundreds of genes Affects ~10% of your genome [ 1 ] Immune regulation Boosts innate immunity and reduces autoimmunity Low levels linked to infections and ]inflammatory disorders [ 2 ] Bone & muscle health Increases calcium absorption

Omega-3s are critical for brain, heart, and immune health — but genetic differences in absorption and conversion mean some people need much more than others. Highlights Function Impact on You Key Insight Brain structure & function DHA is a key component of neuronal membranes Low levels linked to cognitive decline and depression Inflammation control Omega-3s reduce inflammatory cytokines like IL-6 and TNF-α Especially effective in high-inflammation genotypes Heart health EPA a

N-Acetylcysteine is a glutathione-boosting powerhouse with proven benefits for inflammation, mood, and longevity — and your genes may shape your response. Highlights Function Impact on You Key Insight Glutathione precursor Supports detox, immune regulation, and antioxidant defense NAC boosts glutathione — the body’s “master antioxidant” Mental health Lowers glutamate, boosts GABA, and stabilizes mood Used in trials for OCD, bipolar disorder, and substance cravings Lung and li

Magnesium powers over 300 enzymatic reactions in your body — and your genes may determine how much you need. Highlights Function Impact on You Key Insight Enzyme cofactor Supports energy production, DNA repair, and neurotransmission Required by over 300 enzymes across multiple body systems Stress modulation Lowers cortisol and calms the nervous system Linked to better resilience and parasympathetic tone Sleep quality Improves deep sleep and reduces nighttime awakenings Works

The FOX (Forkhead Box)  gene family is a critical group of genes that influence diverse biological processes, including cellular development, metabolism, stress resistance, and longevity. With over 40 FOX genes identified in humans, each plays unique roles in maintaining health and preventing disease [ R ]. Among these, FOXO genes  (FOXO1, FOXO3, FOXO4, and FOXO6) have garnered significant attention due to their association with aging, cancer resistance, and metabolic health.

The TP53 gene, often referred to as the "guardian of the genome," plays a pivotal role in maintaining cellular integrity by regulating the cell cycle, promoting DNA repair, and initiating apoptosis in response to genomic damage. As one of the most studied genes in human biology, TP53 is fundamental to preventing cancer and is implicated in numerous diseases when mutated or dysregulated [ 1 ]. Structure and Function of TP53 Located on chromosome 17 (17p13.1), TP53 encodes the