CETP rs5882 and Your Cholesterol: What It Means

The CETP rs5882 variant, also called Ile405Val, is one of the most studied cholesterol-related genetic markers. It affects how efficiently your body transfers cholesterol between HDL and LDL. Even small shifts in CETP activity can influence your long-term cardiovascular profile.

At GenesUnveiled, we analyze CETP rs5882 as part of your heart-health and lipid-metabolism insights. Upload your DNA at GenesUnveiled to see your full genetic profile.

How CETP rs5882 Influences Cholesterol

Research links CETP rs5882 to several metabolic effects [R]:

• Modulates HDL (“good”) cholesterol levels

• Alters CETP protein activity, which affects cholesterol transport

• Slightly shifts cardiovascular risk depending on genotype

• Helps explain individual variation in response to diet and exercise

These effects are subtle alone, but meaningful when combined with other lipid genes.

What CETP rs5882 Means for You

If you carry the rs5882 G allele, research suggests potential for [R]:

• Slightly higher HDL cholesterol

• Reduced CETP activity → more efficient cholesterol clearance

• A modest trend toward lower cardiovascular risk

If you do not carry this version, your lipid response may follow population-average patterns.

Lifestyle still dominates your cholesterol outcomes—but your CETP genetics help explain why some people respond differently to diet, exercise, and alcohol.

Explore Your CETP rs5882 Result

Upload your raw DNA from 23andMe, Ancestry, or MyHeritage at GenesUnveiled.

Your report will show how CETP rs5882 work in your case.